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Monday 4 April 2005


Definition: Aurora B kinase / AURKB is a protein that functions in the attachment of the mitotic spindle to the centromere.

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases.

The Aurora kinases AURKs associate with microtubules during chromosome movement and segregation.

Aurora kinase B / ARURKB localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers.

Aurora kinase A / AURKA (MIM.603072) localizes to centrosomes (Lampson et al., 2004).


In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer.



See also



- Giet R, Petretti C, Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Trends Cell Biol. 2005 May;15(5):241-50. PMID: 15866028