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AURKB

MIM.604970

Monday 4 April 2005

WKP

Definition: Aurora B kinase / AURKB is a protein that functions in the attachment of the mitotic spindle to the centromere.

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases.

The Aurora kinases AURKs associate with microtubules during chromosome movement and segregation.

Aurora kinase B / ARURKB localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers.

Aurora kinase A / AURKA (MIM.603072) localizes to centrosomes (Lampson et al., 2004).

Pathology

In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer.

Members

|AURKA |AURKB |AURKC |

See also

- AURKA

References

- Giet R, Petretti C, Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Trends Cell Biol. 2005 May;15(5):241-50. PMID: 15866028