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CHFR

MIM.605209

Sunday 3 April 2005

A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints.

Animal models

- CHFR null mice (15793587)

Pathology

- Expression of the mitotic checkpoint protein Chfr is lost in 20-50% of primary tumors and tumor cell lines.