hematopoietic stem cells
Sunday 13 July 2003
Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells.
HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic ’niche’, or microenvironment.
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Orkin SH. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet. 2000 Oct;1(1):57-64. PMID: #11262875#