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hematopoietic stem cells

Sunday 13 July 2003

Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells.

HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic ’niche’, or microenvironment.

References

- Dynamic niches in the origination and differentiation of haematopoietic stem cells. Wang LD, Wagers AJ. Nat Rev Mol Cell Biol. 2011 Sep 2;12(10):643-55. PMID: 21886187

- Chute JP. Stem cell homing. Curr Opin Hematol. 2006 Nov;13(6):399-406. PMID: 17053451

- Orkin SH. Diversification of haematopoietic stem cells to specific lineages. Nat Rev Genet. 2000 Oct;1(1):57-64. PMID: 11262875