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Stem cells

Sunday 13 July 2003

Definition: A self-renewing cell with the potential to give rise to a variety of cells, including progenitor cells.

Subtypes

- embryonic stem cells
- umbilical cord stem cells
- adult stem cells

  • cutaneous stem cells
  • marrow stem cells
  • mesenchymal stem cells

- cancer stem cells

Videos

- Characteristics of Stem Cells (Part 1 of 4)

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- Pluripotent Stem Cells in the Early Embryo (Part 2 of 4)

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- Stem Cells in the Adult Body (Part 3 of 4)

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- Stem cells and development

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- Embryonic Stem Cells in Culture (Part 4 of 4)

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References

- Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007 Sep;8(9):703-13. PMID: 17717515

- Chute JP. Stem cell homing. Curr Opin Hematol. 2006 Nov;13(6):399-406. PMID: 17053451

- Kaufmann WK. Dangerous entanglements. Trends Mol Med. 2006 Jun;12(6):235-7. PMID: 16631407

- Zhang M, Rosen JM. Stem cells in the etiology and treatment of cancer. Curr Opin Genet Dev. 2006 Feb;16(1):60-4. PMID: 16377171

- Eckfeldt CE, Mendenhall EM, Verfaillie CM. The molecular repertoire of the ’almighty’ stem cell. Nat Rev Mol Cell Biol. 2005 Sep;6(9):726-37. PMID: 16103873

- Xi R, Kirilly D, Xie T. Molecular mechanisms controlling germline and somatic stem cells: similarities and differences. Curr Opin Genet Dev. 2005 Jun 9; PMID: 15950455

- Mayhall EA, Paffett-Lugassy N, Zon LI. The clinical potential of stem cells. Curr Opin Cell Biol. 2004 Dec;16(6):713-20. PMID: 15530786

- Zipori D. The nature of stem cells: state rather than entity. Nat Rev Genet. 2004 Nov;5(11):873-8. PMID: 15520797

- Sablowski R. Plant and animal stem cells: conceptually similar, molecularly distinct? Trends Cell Biol. 2004 Nov;14(11):605-11. PMID: 15519849

- Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer. 2003 Dec;3(12):895-902. PMID: 14737120

- Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13350-5. Epub 2003 Oct 31. PMID: 14595015

- Rosenthal N. Prometheus’s vulture and the stem-cell promise.N Engl J Med. 2003 Jul 17;349(3):267-74. PMID: 12867611

- Verfaillie CM. Adult stem cells: assessing the case for pluripotency. Trends Cell Biol. 2002 Nov;12(11):502-8. PMID: 12446111

- Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 2002 Sep;12(9):432-8. PMID: 12220864

- Bjorklund A, Svendsen CN. Chimeric stem cells. Trends Mol Med. 2001 Apr;7(4):144-6. PMID: 11286926

- Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol. 2001;17:387-403. PMID: 11687494

- Tsai RY, Kittappa R, McKay RD. Plasticity, niches, and the use of stem cells. Dev Cell. 2002 Jun;2(6):707-12. PMID: 12062083

- Fuchs E, Segre JA. Stem cells: a new lease on life.
Cell. 2000 Jan 7;100(1):143-55. PMID: 10647939

- Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell. 2000 Jan 7;100(1):157-68. PMID: 10647940