Home > D. Systemic pathology > Immune system diseases > ANCAs

ANCAs

Monday 7 March 2005

Types

- cANCA: diffuse cytoplasmic staining by immunofluorescence

- pANCA: perinuclear staining

  • P-ANCAs are usually directed against myeloperoxidase (MPO)
  • Wegener granulomatosis (5-20%)
  • microscopic polyangiitis ++

- atypical pattern

  • inflammatory bowel disease
  • systemic immune-mediated diseases
  • infections

See also

- ANCA-associated vasculitis