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PR3 - Humpath.com - Human pathology

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PR3

MIM.608710 6p21.3

Monday 7 March 2005

Proteinase-3 is present within primary azurophil granules of neutrophils (PMNs) and lysozymes of monocytes. PR3 translocates to the cell surface, where PR3-ANCAs can interact with their antigens and activate PMNs.

Pathology

- PR3 encodes proteinase-3 that is the target of antineutrophil cytoplasmatic autoantibodies (ANCAs) observed in patients sera with Wegener granulomatosis.