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mesenchymal chondrosarcoma

Friday 4 March 2005


- mesenchymal chondrosarcoma NGS: cartilage islands w/ background of undifferentiated small round cells; HPC-like vessels.


- mixture of undifferentiated small cells and mature hyaline cartilage islands, positive for vimentin, S-100 and CD99.

Molecular biology

- HEY1 and NCOA2 fusion gene : HEY1-NCOA2


- skeletal mesenchymal chondrosarcoma
- extra-skeletal mesenchymal chondrosarcoma


- intracranial mesenchymal chondrosarcoma (17990930)
- neonatal mesenchymal chondrosarcoma (17990930)


- trisomy 8 (15899388)
- translocation der(13;21)(q10;q10) (12011263)
- t(4;9)(q23;q22) (8603349)
- t(1;20)(q21;q13) (8603349)
- t(11;22)(q24;q12) (8281518)
- add(7)(p13) (7656206)
- add(22)(q13) (7656206)


- Gatter KM, Olson S, Lawce H, Rader AE. Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma. Cancer Genet Cytogenet. 2005 Jun;159(2):151-4. PMID: 15899388

- Muller S, Soder S, Oliveira AM, Inwards CY, Aigner T. Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton. Mod Pathol. 2005 Feb 25 PMID: 15731776

- Szymanska J, Tarkkanen M, Wiklund T, Virolainen M, Blomqvist C, Asko-Seljavaara S, Tukiainen E, Elomaa I, Knuutila S. Cytogenetic study of extraskeletal mesenchymal chondrosarcoma. A case report. Cancer Genet Cytogenet. 1996 Feb;86(2):170-3. PMID: 8603349

- Sainati L, Scapinello A, Montaldi A, Bolcato S, Ninfo V, Carli M, Basso G. A mesenchymal chondrosarcoma of a child with the reciprocal translocation (11;22)(q24;q12). Cancer Genet Cytogenet. 1993 Dec;71(2):144-7. PMID: 8281518