Monday 28 February 2005
Major changes occur in the pulmonary circulation at birth. Failure of normal adaptation leads to pulmonary hypertension of the newborn. The basis for this may be abnormal growth of the lung in utero or a failure of the mechanisms which lead to vasodilatation in the newborn period.
endothelial function and dysfunction
nitric oxide (NO)
pulmonary artery pressure
Hislop A. Developmental biology of the pulmonary circulation. Paediatr Respir Rev. 2005 Mar;6(1):35-43. PMID: 15698814
Hislop AA, Pierce CM. Growth of the vascular tree. Paediatr Respir Rev. 2000 Dec;1(4):321-7. PMID: 16263459