Friday 18 February 2005
Definition: Axonal transport is an active, directional transport of organelles and molecules along the axon driven by specific motor proteins running along microtubules. Anterograde and retrograde axonal transport move cargoes away from and towards the cell body, respectively.
fast component (membranous cargoes)
slow component (non-membranous cargoes)
Axonal transport: A movie from J Cell Biol
Gunawardena S, Goldstein LS. Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways. Arch Neurol. 2005 Jan;62(1):46-51. PMID: 15642849
Gunawardena S, Goldstein LS. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol. 2004 Feb 5;58(2):258-71. PMID: 14704957
Goldstein LS. Do disorders of movement cause movement disorders and dementia? Neuron. 2003 Oct 9;40(2):415-25. PMID: 14556718