Thursday 17 February 2005
Members of the GLIs subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links.
The protein Gli2 encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH1) gene expression. It is also thought to play a role during embryogenesis.
mutations of GLI2 in pituitary anomalies with holoprosencephaly-like features (MIM.165230)