Friday 11 February 2005
Both M2A (D2-40) and c-KIT have frequently been used as markers of germ cell tumors. However, comparative studies of their immunoreactivities in human fetal gonads have been limited.
In 12-week fetuses, c-KIT immunoreactivity is weak, but M2A immunoreactivity is consistently strong.
At 15 and 18 weeks of gestation, c-KIT immunoreactivity is found in most germ cells.
D2-40 is expressed in Sertoli cells as well as in germ cells, but is not expressed in ovarian follicles undergoing meiosis.
D2-40 appears to be a more useful marker of germ cells than c-KIT in human fetal testis and ovary at the second trimester.
D2-40 is also reactive in fetal Sertoli cells, but its expression is consistently weaker than in germ cells.
fetal testis 39 weeks
A comparison between D2-40 and c-KIT immunohistochemistry for the human fetal testis and ovary at the second trimester of gestation. Jin ZW, Kim YG, Yu HC, Murakami G, Fujimiya M, Cho BH. Okajimas Folia Anat Jpn. 2010 May;87(1):1-4. PMID: #20715565#