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periportal necrosis

Wednesday 9 February 2005

Definition: Periportal hepatocytic necrosis is the necrosis of hepatocytes localized around the portal vein. It is usually associated with ingested toxins.

Periportal necrosis rather than the more usual perivenular necrosis is a feature in some patients with hepatitis A.

Etiology

- toxic hepatitis

  • ferrous sulfate intoxication
  • yellow phosphorus toxicity
  • acetic acid ingestion

- hepatitis A

References

- The diagnostic significance of periportal hepatic necrosis and inflammation (Link)