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mitosis

Sunday 13 July 2003

Images

- in a glandular epithelium

- in epidermis

- numerous atypical mitoses

Final steps

The final stages of mitosis begin in anaphase, when the mitotic spindle segregates the duplicated chromosomes. Mitotic exit is then completed by disassembly of the spindle and packaging of chromosomes into daughter nuclei.

The successful completion of mitosis requires that these events occur in a strict order. Two main mechanisms govern progression through late mitosis: dephosphorylation of cyclin-dependent kinase (Cdk) substrates and destruction of the substrates of the anaphase-promoting complex (APC).

Pathology

- abnormal mitosis / abnormal mitoses
- high mitotic activity

See also

- mitotic spindle
- centrosomes
- cell cycle
- mitosis anomalies

Videos

- animal cell division

- plant cell division

- mitosis

References

- Mechanisms of chromosome behaviour during mitosis. Walczak CE, Cai S, Khodjakov A. Nat Rev Mol Cell Biol. 2010 Feb;11(2):91-102. PMID: 20068571

- Sullivan M, Morgan DO. Finishing mitosis, one step at a time.
Nat Rev Mol Cell Biol. 2007 Nov;8(11):894-903. PMID: 17912263

- Pines J. Mitosis: a matter of getting rid of the right protein at the right time. Trends Cell Biol. 2006 Jan;16(1):55-63. PMID: 16337124

- Moore A, Wordeman L. The mechanism, function and regulation of depolymerizing kinesins during mitosis. Trends Cell Biol. 2004 Oct;14(10):537-46. PMID: 15450976

- O’Connell MJ, Krien MJ, Hunter T. Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol. 2003 May;13(5):221-8. PMID: 12742165

- O’Farrell PH. Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 2001 Dec;11(12):512-9. PMID: 11719058

- Adams RR, Carmena M, Earnshaw WC. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol. 2001 Feb;11(2):49-54. PMID: 11166196

- Gardner RD, Burke DJ. The spindle checkpoint: two transitions, two pathways. Trends Cell Biol. 2000 Apr;10(4):154-8. PMID: 10740270