MIM.601045 11q11 HGNC:2515
Monday 31 January 2005
IHC diagnostic use
p120 stain in breast biopsy showing LCIS, ILC, DCIS and IDC in same biopsy
DCIS vs LCIS differential diagnosis
- Breast carcinoma in situ (CIS) is classified into ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS).
- DCIS is treated with surgical excision while LCIS can be clinically followed with or without hormonal treatment. Thus, it is critical to distinguish DCIS from LCIS.
- Immunohistochemical (IHC) staining for E-cadherin is routinely used to differentiate DCIS from LCIS in diagnostically challenging cases.
- Circumferential diffuse membranous staining of E-cadherin is the typical pattern in DCIS, whereas LCIS lacks or shows decreased E-cadherin expression.
- DCIS has membranous staining of P120 catenin and LCIS has diffuse cytoplasmic staining of P120 catenin.
- IHC cocktails composed of E-cadherin and P120 catenin primary antibodies have been developped for a double immunostains. (24966968)
Diagnostic utility of E-cadherin and P120 catenin cocktail immunostain in distinguishing DCIS from LCIS. Li X, Schwartz MR, Ro J, Hamilton CR, Ayala AG, Truong LD, Zhai QJ. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2551-7. PMID: 24966968 (Free)
CTNNs (catenins )
- CTNNDs ( D catenins )