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CTNND1

MIM.601045 11q11 HGNC:2515

Monday 31 January 2005

delta-cadherin; p120

IHC diagnostic use

- p120 stain in breast biopsy showing LCIS, ILC, DCIS and IDC in same biopsy

- DCIS vs LCIS differential diagnosis

  • Breast carcinoma in situ (CIS) is classified into ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS).
  • DCIS is treated with surgical excision while LCIS can be clinically followed with or without hormonal treatment. Thus, it is critical to distinguish DCIS from LCIS.
  • Immunohistochemical (IHC) staining for E-cadherin is routinely used to differentiate DCIS from LCIS in diagnostically challenging cases.
  • Circumferential diffuse membranous staining of E-cadherin is the typical pattern in DCIS, whereas LCIS lacks or shows decreased E-cadherin expression.
  • DCIS has membranous staining of P120 catenin and LCIS has diffuse cytoplasmic staining of P120 catenin.
  • IHC cocktails composed of E-cadherin and P120 catenin primary antibodies have been developped for a double immunostains. (24966968)

Open references

- Diagnostic utility of E-cadherin and P120 catenin cocktail immunostain in distinguishing DCIS from LCIS. Li X, Schwartz MR, Ro J, Hamilton CR, Ayala AG, Truong LD, Zhai QJ. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2551-7. PMID: 24966968 (Free)

See also

- CTNNs (catenins )

  • CTNNDs ( D catenins )

References

- Kosik KS, Donahue CP, Israely I, Liu X, Ochiishi T. Delta-catenin at the synaptic-adherens junction. Trends Cell Biol. 2005 Mar;15(3):172-8. PMID: 15752981

Portfolio

  • Delta-catenin and adherens junction