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MALT1

MIM.604860 18q21

Monday 31 January 2005

Pathology

Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3/MALT1 and IGH/MALT1 respectively, and activate the NF-kappaB pathway.

- BIRC3/MALT1 fusion gene by t(11;18)(q21;q21) translocation in low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALToma)

- IGH-MALT1 by t(14;18)(q32;q21) in extranodal diffuse large B-cell lymphoma

- MALT1/MAP4 gene fusion occurs in diffuse large B-cell lymphoma (#16804917#)

References

- Murga Penas EM, Kawadler H, Siebert R, Frank M, Ye H, Hinz K, Becher C, Hummel M, Barth TF, Bokemeyer C, Stein H, Trumper L, Moller P, Marynen P, Du MQ, Yang X, Hansmann ML, Dierlamm J. A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma. Genes Chromosomes Cancer. 2006 Sep;45(9):863-73. PMID: #16804917#