Monday 31 January 2005
Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3/MALT1 and IGH/MALT1 respectively, and activate the NF-kappaB pathway.
BIRC3/MALT1 fusion gene by t(11;18)(q21;q21) translocation in low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALToma)
IGH-MALT1 by t(14;18)(q32;q21) in extranodal diffuse large B-cell lymphoma
Murga Penas EM, Kawadler H, Siebert R, Frank M, Ye H, Hinz K, Becher C, Hummel M, Barth TF, Bokemeyer C, Stein H, Trumper L, Moller P, Marynen P, Du MQ, Yang X, Hansmann ML, Dierlamm J. A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma. Genes Chromosomes Cancer. 2006 Sep;45(9):863-73. PMID: 16804917