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leucocytic adhesion

Sunday 30 January 2005

Leukocyte adhesion and transmigration are regulated largely by the binding of complementary adhesion molecules on the leukocyte and endothelial surfaces, and chemical mediators-chemoattractants and certain cytokines-affect these processes by modulating the surface expression or avidity of such adhesion molecules.

The adhesion receptors involved belong to four molecular families:
- selectins (SELs)
- immunoglobulin superfamily (ICAMs)
- integrins (ITGs)
- mucin-like glycoproteins (like heparan sulfate).

References

- Rhee JS, Santoso S, Herrmann M, Bierhaus A, Kanse SM, May AE, Nawroth PP, Colman RW, Preissner KT, Chavakis T. New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products. Curr Mol Med. 2003 Jun;3(4):387-92. PMID: 12776993