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TCR signaling pathway

Wednesday 26 January 2005

Following the interaction of antigen-presenting cells (APCs) such as dendritic cells with T cells, the T cell receptor (TCR) signalling pathway leads to early events such as the phosphorylation of the TCR, release of Ca2+, and the recruitment and activation of non-receptor tyrosine kinases and adapter proteins.

In the context of actin cytoskeleton remodeling, the Arp2/3 complex and Ena/VASP proteins co-localise at the immunological synapse, the structure that is assembled when T cells interact with APCs, and that are required for efficient actin cytoskeleton dynamics at this site.

The functions of the Arp2/3 complex and Ena/VASP proteins are co-ordinated through the formation of a similar multi-molecular complex during Fcγ receptor-mediated phagocytosis. Thus, the assembly of such complexes is a general mechanism underlying actin cytoskeleton dynamics in haematopoietic cells. Signalling pathways leading to actin cytoskeleton remodeling in dendritic cells that are crucial for T-cell activation and DC cell motility.

References

- Wange RL. TCR signaling: another Abl-bodied kinase joins the cascade. Curr Biol. 2004 Jul 27;14(14):R562-4. PMID: 15268875