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axonal guidance

Wednesday 26 January 2005

Eph-ephrin signaling

Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in trans on opposing cells. In the developing nervous system, the Eph-ephrin signaling system controls a large variety of cellular responses including contact-mediated attraction or repulsion, adhesion or de-adhesion, and migration.

Eph-ephrin signaling can be bidirectional, and is subject to modulation by ectodomain cleavage of ephrins and by Eph-ephrin endocytosis.

References

- Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance.
Trends Cell Biol. 2007 Apr 7; PMID: #17420126#

- Eichmann A, Makinen T, Alitalo K. Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes Dev. 2005 May 1;19(9):1013-21. PMID: #15879551#

- Lee JS, Chien CB. When sugars guide axons: insights from heparan sulphate proteoglycan mutants. Nat Rev Genet. 2004 Dec;5(12):923-35. PMID: #15573124#

- Guthrie S. Axon guidance: mice and men need Rig and Robo. Curr Biol. 2004 Aug 10;14(15):R632-4. PMID: #15296783#

- Araujo SJ, Tear G. Axon guidance mechanisms and molecules: lessons from invertebrates. Nat Rev Neurosci. 2003 Nov;4(11):910-22. PMID: #14595402#

- Baas PW, Ahmad FJ. Force generation by cytoskeletal motor proteins as a regulator of axonal elongation and retraction. Trends Cell Biol. 2001 Jun;11(6):244-9. PMID: #11356360#