Home > E. Pathology by systems > Skin > cutaneous squamous cell carcinoma
cutaneous squamous cell carcinoma
Wednesday 26 January 2005
cutaneous epidermoid carcinoma; cutaneous SCC
Digital cases
UI:94 : Cutaneous squamous cell carcinoma.
UI:314 : Cutaneous squamous cell carcinoma.
JRC:10409 : Cutaneous epidermoid carcinoma.
Definition: Cutaneous squamous cell carcinomas (SCC) are the second most commonly diagnosed cancers in fair-skinned people.
Images
Scalp lesion in old man : sarcomatoid squamous cell carcinoma S100- SOX10- CKAE1/AE3+
Variants
cutaneous sarcomatoid squamous cell carcinoma
See also
sarcomatoid carcinomas
squamous cell carcinoma (SCC)
Allelotyping
9p LOH
3p LOH
9 LOH
2q LOH
8p LOH
13 LOH
Allelic gain
3q AG
8q AG
-copy number-neutral LOH
homozygous microdeletion on 9p23 at the protein tyrosine phosphatase receptor type D (PTPRD) locus
References
Purdie KJ, Lambert SR, Teh MT, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM, Harwood CA, Proby CM, Young BD. Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer. 2007 Jul;46(7):661-9. PMID: 17420988
Lima-Bessa KM, Menck CF. Skin cancer: lights on genome lesions. Curr Biol. 2005 Jan 26;15(2):R58-61. PMID: 15668158
