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dyslexia

Tuesday 18 January 2005

Etiology

Four genes have recently been proposed as candidates for dyslexia:

- dyslexia susceptibility 1 candidate 1 (DYX1C1)
- roundabout Drosophila homolog 1 (ROBO1)
- doublecortin domain-containing protein 2 (DCDC2)
- KIAA0319.

Each gene is implicated in global brain-development processes such as neural migration and axonal guidance, with the exception of DYX1C1, the function of which is still unknown.

Predisposition loci

- 6p22.2 (15514892, 15717286)

References

- McGrath LM, Smith SD, Pennington BF. Breakthroughs in the search for dyslexia candidate genes. Trends Mol Med. 2006 Jul;12(7):333-41. PMID: 16781891