Loffler endocarditis

Loffler endocarditis is characterized by an eosinophilic endomyocardial fibrosis. Loffler endocarditis refers to the cardiac component of the hypereosinophilic syndromes, which determines patient morbidity and mortality.

Pathological synopsis

 mature eosinophils infiltrate
 damage to the endocardium and myocardium

Clinical synopsis

 weight loss
 fever
 cough
 rash
 congestive heart failure

Etiology

 hypereosinophilic syndrome (HES)
 eosinophilic leukemia
 carcinomas
 lymphomas
 drug reactions
 parasitic infections

Associations

 pulmonary infiltrates
 peripheral eosinophilia