Humpath.com - Human pathology

Home > A. Molecular pathology > SARAs

SARAs

Monday 13 December 2004

SARAs are the Sar1-ADP-ribosylation factor family of small GTPases, which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles.

SARAs family of proteins initiates the intracellular transport of proteins in COPII (coat protein)-coated vesicles.

Members

SARA1 SARA2

See also

- COPI vescicles
- COPII vesicles

Pathology

- germline mutations of the SARA1 and SARA2 genes in

  • chylomicron retention disease (MIM.246700)
  • Anderson disease (MIM.607689)
  • chylomicron retention disease with Marinesco-Sjogren syndrome (MIM.607692)

References

- Shoulders CC, Stephens DJ, Jones B. The intracellular transport of chylomicrons requires the small GTPase, Sar1b. Curr Opin Lipidol. 2004 Apr;15(2):191-7. PMID: 15017362