Humpath.com - Human pathology

Home > D. General pathology > Blood and immunity > Dysimmune diseases > light chain deposition disease

light chain deposition disease

Friday 10 December 2004

light-chain–deposition disease, light chain deposit disease, light chain amyloid deposition

Pathogeny

Local microenvironmental conditions affect the ultrastructural organization of protein deposits. For example, pH influences the processing of immunoglobulin light chains, causing them to form either fibrillar amyloid aggregates or amorphous aggregates characteristic of light-chain–deposition disease.

Association

- POEMS syndrome

References

- Unique Pattern of Renal κ Light Chain Amyloid Deposition With Histiocytic Transdifferentiation of Tubular Epithelial Cells. Hemminger J, Satoskar A, Brodsky SV, Calomeni E, Nadasdy GM, Kovach P, Hofmeister CC, Nadasdy T. Am J Surg Pathol. 2012 Aug;36(8):1253-7. PMID: 22790864