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NSAIDs

Monday 22 November 2004

Pathology

- NSAID fetopathy (in utero exposure)

  • oligohydramnios
  • bleeding diathesis
  • ileal perforation
  • premature closure of the ductus
  • acute or chronic renal injury
  • renal tubular dysgenesis
  • renal structural abnormalities
  • uncertain or incomplete tubular differentiation with immature tubule

References

- Caselli M, LaCorte R, DeCarlo L, Aleotti A, Trevisani L, Ruina M, Trotta F, Alvisi V. Histological findings in gastric mucosa in patients treated with non-steroidal anti-inflammatory drugs. J Clin Pathol. 1995 Jun;48(6):553-5. PMID: #7665699#

- Benini D, Fanos V, Cuzzolin L, Tato L. In utero exposure to nonsteroidal anti-inflammatory drugs: neonatal renal failure. Pediatr Nephrol. 2004 Feb;19(2):232-4. PMID: #14648334#