WNT signaling pathway
Thursday 10 July 2003
WNT signalling has a key role in early embryonic patterning through the regulation of cell fate decisions, tissue polarity and cell movements.
Wnt signal transduction is crucial for maintaining the balance between proliferation and differentiation throughout embryogenesis and postnatal life.
In the vertebrate embryo, the formation of the dorsal-ventral axis depends on the activity of the Wnt signaling pathway.
Pathology of the Wnt/beta-catenin pathway
- colonic cancer predisposition
mutations in AXIN2 predispose to colonic adenocarcinoma (15042511)
- Anonychia is an autosomal recessive disorder characterized by the congenital absence of finger- and toe-nails.
- RSPO4 is a member of the recently described R-spondin family of secreted proteins that play a major role in activating the Wnt/ beta -catenin signaling pathway.
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