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glucuronidation

Monday 22 November 2004

Glucuronidation represents a major pathway which enhances the elimination of many lipophilic xenobiotics and endobiotics to more water-soluble compounds.

UDP-glucuronosyltransferases (UDPGTs) catalyze the addition of the glycosyl group from a nucleotide sugar to a small hydrophobic molecule (aglycone).

The conserved superfamily proteins all contain a 44-amino acid signature sequence in their C-terminal halves.

Pathology

- germline mutations of UGT1A1 in Crigler-Najjar disease