Home > E. Pathology by systems > Genital system > Female genital system > Uterus > endometrial polyp
endometrial polyp
Wednesday 17 November 2004
Clinical synopsis
asymptomatic or associated with bleeding associated with tamoxifen therapy for breast cancer
MAcroscopy synopsis
sessile or pedunculated mass cystically dilated glands multicystic cut surface
Microscopy synopsis
endometrial glands unresponsive to progesterone stimulation may have severe atypia fibrous stroma with spindled fibroblast-like cells abundant extracellular connective tissue polypoid shape attenuated surface endometrium on 3 sides cystic change proliferative glands or inactive inactive rare atypical stromal cells polypoid shape surface epithelium on three sides dense stroma +/- fibrous stroma large and thick-walled arteries glands more irregular, tortuous and dilated than normal endometrial glands ’out of phase’ appearance of endometrial glands hyperplastic endometrial glands
Physiopathology
may represent circumscribed foci of endometrial hyperplasia
Types
common endometrial polyps
- proliferative hyperplastic endometrial polyp
- atrophic endometrial polyp
- functionnal endometrial polyp
- mixed endometrial-endocervical endometrial polyp
- adenomyomatous endometrial polyp
atypical polypid adenocarcinoma
Differential diagnosis
basalis endometrium lower uterine segment endometrial hyperplasia (stromal cells have large vesicular nuclei and mitotic figures)
