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smooth muscle actin

Sunday 31 October 2004

SMA; Actin (Smooth Muscle)

IHCDB

Definition: An anti-SMA antibody labels smooth muscle cells, myofibroblasts and myoepithelial cells, and is useful for the identification of leiomyomas, leiomyosarcomas, and pleomorphic adenomas.

It is expressed by :
- myofibroblastic tumors
- smooth muscle tumors as leiomyomas and leiomyosarcomas
- some skeletal muscle tumors as some rhabdomyosarcomas

See also

- actin microfilaments
- immunohistochemical markers