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megacystis

Tuesday 12 October 2004

Etioogy

- fetal urethral obstruction (obstructive megacystis)

  • meconium in the urinary bladder (congenital rectovesical fistula)
  • urethral atresia (agenesis of the posterior urethra) with or without anorectal agenesis
  • posterior urethral valve

- non-obstructive megacystis

  • intestinal neuronal dysplasia
  • vesical myopathy (visceral myopathy)
    • megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS)
      • trisomy 18

- chromosomal anomalies

  • trisomy 13
  • trisomy 18
  • trisomy 21

Mouse models

- mgb mouse: transgenic mutant mouse model with in utero megabladder, hydroureteronephrosis, chronic renal failure secondary to obstructive uropathy (primary defect in bladder smooth muscle development) (#17202422#)

See also

- Prune-Belly sequence

Case records

- Case record #10087
- Case record #11183: megacystis-microcolon syndrome
- Case record #11598: Megacystis in urethral obstruction sequence (UOS) with prune belly syndrome

References

- McHugo J, Whittle M. Enlarged fetal bladders: aetiology, management and outcome. Prenat Diagn. 2001 Nov;21(11):958-63. PMID: #11746149#

Portfolio

  • Megacystis with abdominal distension by urethral atresia
  • Megacystis with abdominal distension by urethral atresia
  • Megacystis
  • Megacystis
  • Megacystis with abdominal distension by urethral obstruction
  • Megacystis with abdominal distension by urethral obstruction
  • Megacystis with bilateral megaureteres
  • Megacystis with abdominal distension by urethral atresia
  • Megacystis with abdominal distension by urethral atresia
  • Megacystis-microcolon syndrome (Case #11183)
  • Megacystis-microcolon syndrome (Case #11183)
  • Megacystis-microcolon syndrome (Case #11183)
  • Prune belly sequence by urethral obstruction sequence with megacystis (Case (...)
  • Prune belly sequence by urethral obstruction sequence with megacystis (Case (...)
  • Prune belly sequence by urethral obstruction sequence with megacystis (Case (...)
  • Prune belly sequence by urethral obstruction sequence with megacystis (Case (...)