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VCP

9p13-p12

Tuesday 12 October 2004

VCP is a A 100-kD protein, designated valosin-containing protein. This structural protein is complexed with clathrin. clathrin is a structural protein found in coated pits and vesicles, organelles which are important in membrane trafficking functions such as endocytosis and Golgi sorting.

Pathology

- germline mutations in autosomal dominant IBMPFD - inclusion body myopathy with early-onset paget disease and frontotemporal dementia (MIM.605382)