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Monday 4 October 2004

- The generation of somites, and the subsequent formation of their major derivatives, muscle-, cartilage-, dermis- and tendon-cell lineages, is tightly orchestrated and, to different extents, these are also mutually supporting processes.

- They involve complex and timely reorganizations of the paraxial mesoderm, such as multiple phases of epithelial-mesenchymal rearrangements and vice-versa, cellular movements and migrations, and modifications of both cell shape and cell cycle properties.

- These morphogenetic changes are triggered by local environmental signals and are tightly associated to a genetic program imparting cell-specific fates.

See also

- vertebral segmentation (somites segmentation)
- somitogenesis


- Chong SW, Jiang YJ. Off limits—integrins holding boundaries in somitogenesis. Trends Cell Biol. 2005 Sep;15(9):453-7. PMID: 16087338

- Kalcheim C, Ben-Yair R. Cell rearrangements during development of the somite and its derivatives. Curr Opin Genet Dev. 2005 Jun 9; PMID: 15950454