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cetuximab

Friday 24 September 2004

Erbitux

Definition: Cetuximab (Erbitux) is a monoclonal antibody designed to bind specifically to EGFR and block certain growth factors from binding and signaling the cell to promote tumor cell growth, survival, and progression.

Indications

- treatment of EGFR-expressing metastatic colorectal cancer

See also

- EGFR

References

- Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, Rougier P, Lievre A, Landi B, Boige V, Ducreux M, Ychou M, Bibeau F, Bouché O, Reid J, Stone S, Penault-Llorca F. J Clin Oncol. 2009 Dec 10;27(35):5924-30. PMID: 19884556