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SLIT2

4p15.2

Tuesday 21 September 2004

Functions

- Slit2 plays a vital role in axon guidance by signaling through Robo receptors (ROBOs), like ROBO1.

- Slit2 has been shown to inhibit leukocyte chemotaxis.

- SLIT2 protein is a putative ligand for the ROBO receptors.

Pathology

- SLIT2 is frequently inactivated by promoter region hypermethylation and allele loss in pulmonary carcinomas and mammary carcinomas (12384551)

  • Promoter hypermethylation has been shown to be a common mechanism for inactivation of tumor suppressor genes in breast cancer.
  • Slit2 promoter hypermethylation is associated with loss of Slit2 expression. (21894562)
  • Slit2 promoter hypermethylation appears to be responsible for functionally silencing Slit2 expression. (21894562)
  • Slit2 promoter hypermethylation may be considered as a possible serum marker for early detection of breast cancer. (21894562)

References

- Detection of Slit2 promoter hypermethylation in tissue and serum samples from breast cancer patients. Kim GE, Lee KH, Choi YD, Lee JS, Lee JH, Nam JH, Choi C, Park MH, Yoon JH. Virchows Arch. 2011 Sep 6. PMID: 21894562