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MET

MIM.164860 7q31 HGNC:7029

Tuesday 21 September 2004

c-met; MET protooncogene, HGFR, RCCP2, hepatocyte growth factor/scatter factor (HGF/SF) receptor; met proto-oncogene (hepatocyte growth factor receptor); HGFR, RCCP2

Pathology

- germline activating mutations in:

  • familial papillary renal carcinoma (MIM.605074)
  • familial colorectal cancer (#21970370#)

- somatic activating mutations in:

  • sporadic papillary renal carcinoma (MIM.605074)
  • childhood type hepatocellular carcinoma (MIM.114550)

References

- Activating mutation in MET oncogene in familial colorectal cancer. Neklason DW, Done MW, Sargent NR, Schwartz AG, Anton-Culver H, Griffin CA, Ahnen DJ, Schildkraut JM, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Burt RW. BMC Cancer. 2011 Oct 4;11:424. PMID: #21970370#

- Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms. Hansel DE, Rahman A, House M, Ashfaq R, Berg K, Yeo CJ, Maitra A. Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6152-8. PMID: #15448002#

- Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Lae M, Fisher DE, Ladanyi M. TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res. 2007 Feb 1;67(3):919-29. PMID: #17283122#

- Chen Y, Takita J, Mizuguchi M, Tanaka K, Ida K, Koh K, Igarashi T, Hanada R, Tanaka Y, Park MJ, Hayashi Y. Mutation and expression analyses of the MET and CDKN2A genes in rhabdomyosarcoma with emphasis on MET overexpression. Genes Chromosomes Cancer. 2007 Apr;46(4):348-58. PMID: #17243166#

- Corso S, Comoglio PM, Giordano S. Cancer therapy: can the challenge be MET? Trends Mol Med. 2005 Jun;11(6):284-92. PMID: #15949770#

- Dharmawardana PG, Giubellino A, Bottaro DP. Hereditary papillary renal carcinoma type I. Curr Mol Med. 2004 Dec;4(8):855-68. PMID: #15579033#

- Rosario M, Birchmeier W. How to make tubes: signaling by the Met receptor tyrosine kinase. Trends Cell Biol. 2003 Jun;13(6):328-35. PMID: #12791299#