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MIM.603526 14q32.3

Tuesday 14 September 2004

MTA1 is a metastasis-associated gene with histone deacetylase activity.


-  MTA1 has been identified as a metastasis-promoting gene

  • MTA1 gene expression is correlated with serosal invasion and lymph node metastasis in the gastrointestinal and esophageal cancers
  • MT1A is overexpressed in pancreatic carcinomas (MT1A is involved in the progression, particularly in lymph node metastasis.)