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keratoacanthoma
Monday 13 June 2011
keratoacanthomas ; SCC keratoacanthoma type
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Definition : Keratoacanthoma (KA) is a well differentiated, cutaneous squamous cell carcinoma (cutaneous SCC), which can spontaneously regress.
Images
Keratoacanthoma
Keratoacanthomatous atypical squamous proliferations arising in skin graft sites
Synopsis
large, well differentiated squamous tumor
central keratin filled crater / invaginating crateriform tumor
Surrounding epidermis forms a lip around the invaginating crateriform tumor
Tumor is composed of bland squamous cells with :
- abundant eosinophilic cytoplasm or glassy cytoplasm
- enlarged nuclei , hyperchromatic nuclei to vesicular nuclei
mitotic activity and cellular atypia are usually seen at the periphery of tumor
intraepidermal neutrophilic microabscesses
keratin horn pearls
Regressing tumors show :
epidermal atrophy
bland cells / bland cytologic features
dermal inflammation
peripheral fibrosis / fibrosis at the periphery of tumor
Localization
Digital cases
UI:915 : Keratoacanthoma.
JRC:10547 : Keratoacanthoma.
Synopsis
crateriform anomaly / crateriform
Differential diagnosis
keratoacanthoma-like squamous proliferation
See also
