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Home > E. Pathology by systems > Reproductive system > Fetus and annexes > Embryo and fetus > zygote


Tuesday 24 August 2004

Following fertilization, the two specified gametes must unite to create an entirely new organism. The genome is initially transcriptionally quiescent, allowing the zygote to be reprogrammed into a totipotent state. Gradually, the genome is activated through a process known as the maternal-to-zygotic transition, which enables zygotic gene products to replace the maternal supply that initiated development.

Paywall References

- Mechanisms regulating zygotic genome activation. 2018. Nature Reviews Genetics

- DeRenzo C, Seydoux G. A clean start: degradation of maternal proteins at the oocyte-to-embryo transition. Trends Cell Biol. 2004 Aug;14(8):420-6. PMID: 15308208