Tuesday 24 August 2004
20q13 amplification in tumors
Amplification at 20q13 occurs in a variety of tumor types and is associated with aggressive tumor behavior. Kallioniemi et al. (1994) found increased copy number involving 20q13 in 40% of breast cancer cell lines and 18% of primary breast tumors.
Other comparative genomic hybridization studies revealed copy number gains at 20q13 in greater than 25% of cancers of the ovary (ovarian carcinomas), colon (colonic adenocarcinomas), head and neck (head and neck carcinomas), brain (cerebral tumors), and pancreas (pancreatic carcinomas).