Tuesday 24 August 2004
Conventional myxoid chondrosarcoma is composed of lobules of uniform spindle cells with limited eosinophilic cytoplasm forming a delicate reticular pattern in a myxoid background.
The rare high-grade variant of extraskeletal myxoid chondrosarcoma is characterized by cords of large epithelioid cells in a myxoid matrix. Like conventional extraskeletal myxoid chondrosarcoma, the high grade form may show rhabdoid cytomorphology, mimicking the plasmacytoid cells with nuclear atypia seen in some myoepithelial carcinomas.
Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by recurrent chromosome translocations resulting in fusions of the nuclear receptor TEC to various NH(2)-terminal partners.
myoepithelia carcinoma of soft tissue
soft tisue myoepithelioma
SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma. Kohashi K, Oda Y, Yamamoto H, Tamiya S, Oshiro Y, Izumi T, Taguchi T, Tsuneyoshi M. Am J Surg Pathol. 2008 Aug;32(8):1168-74. PMID: 18580682