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gliomatosis peritonei

Monday 23 August 2004

Definition: Gliomatosis peritonei is characterized by the occurrence of nodules of mature glial tissues in the peritoneum.

Gliomatosis peritonei is a rare condition that occurs almost exclusively in the setting of ovarian immature teratoma.

It is controversial whether glial tissues are derived from maturation of the associated teratomatous tissue that has implanted in the peritoneum, or glial differentiation of subperitoneal stem cells.


- mature teratoma
- immature teratoma
- gliomatosis peritonei and endometriosis (21293285, 7928061, 3338678, 7167411)
- ventriculo-peritoneal shunt (19070703, 10726696, 2648802)


- ascite
- malignant transformation (9195578, 2048608)

Molecular biology

In 5 informative cases, the normal tissues showed a heterozygous pattern in the microsatellite loci, the associated teratomas showed a homozygous pattern, and the glial tissues showed a heterozygous pattern. (15188134).

Thus, gliomatosis peritonei is genetically unrelated to the associated teratoma but is probably derived from non-teratomatous cells, such as through metaplasia of submesothelial cells.

Open references

- Gliomatosis peritonei: a clinicopathologic and immunohistochemical study of 21 cases. Liang L, Zhang Y, Malpica A, Ramalingam P, Euscher ED, Fuller GN, Liu J. Mod Pathol. 2015 Dec;28(12):1613-20. doi : 10.1038/modpathol.2015.116 PMID: 26564007


- Gliomatosis peritonei associated with a ventriculo-peritoneal shunt. Lobotesis K, U-King-Im JM, Cross JJ, Gillard JH, Antoun NM. Clin Radiol. 2009 Jan;64(1):95-9. PMID: 19070703

- Molecular analysis of an immature ovarian teratoma with gliomatosis peritonei and recurrence suggests genetic independence of multiple tumors. Best DH, Butz GM, Moller K, Coleman WB, Thomas DB. Int J Oncol. 2004 Jul;25(1):17-25. PMID: 15201985

- Is gliomatosis peritonei derived from the associated ovarian teratoma? Kwan MY, Kalle W, Lau GT, Chan JK. Hum Pathol. 2004 Jun;35(6):685-8. PMID: 15188134

- Kwan MY, Kalle W, Lau GT, Chan JK. Is gliomatosis peritonei derived from the associated ovarian teratoma? Hum Pathol. 2004 Jun;35(6):685-8. PMID: 15188134

- Glial implants in gliomatosis peritonei arise from normal tissue, not from the associated teratoma. Ferguson AW, Katabuchi H, Ronnett BM, Cho KR. Am J Pathol. 2001 Jul;159(1):51-5. PMID: 11438453

- Gliomatosis peritonei as a complication of a ventriculoperitoneal shunt: case report and review of the literature. Hill DA, Dehner LP, White FV, Langer JC. J Pediatr Surg. 2000 Mar;35(3):497-9. Review. PMID: 10726696

- Gliomatosis peritonei with malignant transformation. Dadmanesh F, Miller DM, Swenerton KD, Clement PB. Mod Pathol. 1997 Jun;10(6):597-601. PMID: 9195578

- Immature ovarian teratoma with mature peritoneal metastatic deposits showing glial, epithelial, and endometrioid differentiation: a case report and review of the literature. Calder CJ, Light AM, Rollason TP. Int J Gynecol Pathol. 1994 Jul;13(3):279-82. PMID: 7928061

- Gliomatosis peritonei with malignant transformation: a case report and review of the literature. Shefren G, Collin J, Soriero O. Am J Obstet Gynecol. 1991 Jun;164(6 Pt 1):1617-20; PMID: 2048608

- Gliomatosis peritonei in childhood and adolescence. Clinicopathological study of 13 cases including immunohistochemical findings. Harms D, Jänig U, Göbel U. Pathol Res Pract. 1989 Apr;184(4):422-30. PMID: 2726609

- Gliomatosis peritonei associated with a ventriculoperitoneal shunt. Lovell MA, Ross GW, Cooper PH. Am J Clin Pathol. 1989 Apr;91(4):485-7. PMID: 2648802

- Gliomatosis peritonei with endometriosis externa. Dworák O, Knöpfle G, Varchmin-Schultheiss K, Meyer G. Gynecol Oncol. 1988 Feb;29(2):263-6. PMID: 3338678

- Nodular and tumorlike gliomatosis peritonei with endometriosis caused by a mature ovarian teratoma. Bässler R, Theele C, Labach H. Pathol Res Pract. 1982 Dec;175(4):392-403. PMID: 7167411