Home > D. Systemic pathology > Hematopathology > chronic myeloid leukemia

chronic myeloid leukemia

Monday 23 August 2004

AGCOH

Digital slides

- UI:483 - Chronic myelogenous leukemia

Evolution

- acute leukemias

  • acute erythroid leukemia

Cytogenetics

Most patients with chronic myelogenous leukemia (CML) show a Philadelphia (Ph) chromosome with a characteristic translocation between chromosomes 9 and 22.

There are variant complex translocations involving other chromosomes in addition to the standard translocation:
- t(4;12;7;9;22) (18474301)

Molecular biology

- BCR-ABL fusion protein expression by t(9;22)

CGH (17696194, 16425296)

- chromosomal losses

- chromosomal gains

Links

- AGCOH - Atlas of Genetics and Cytogenetics in Oncology and Haematology

Reviews

- Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer. 2007 Jun;7(6):441-53. PMID: 17522713

- Goldman JM, Melo JV. Chronic myeloid leukemia—advances in biology and new approaches to treatment. N Engl J Med. 2003 Oct 9;349(15):1451-64. PMID: 14534339

References

- MLPA is a powerful tool for detecting lymphoblastic transformation in chronic myeloid leukemia and revealing the clonal origin of relapse in pediatric acute lymphoblastic leukemia. Alpár D, de Jong D, Savola S, Yigittop H, Kajtár B, Kereskai L, Pajor L, Szuhai K. Cancer Genet. 2012 Sep;205(9):465-9. PMID: 22939399

- Brazma D, Grace C, Howard J, Melo JV, Holyoke T, Apperley JF, Nacheva EP. Genomic profile of chronic myelogenous leukemia: Imbalances associated with disease progression. Genes Chromosomes Cancer. 2007 Aug 15; PMID: 17696194

- Hosoya N, Sanada M, Nannya Y, Nakazaki K, Wang L, Hangaishi A, Kurokawa M, Chiba S, Ogawa S. Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization. Genes Chromosomes Cancer. 2006 May;45(5):482-94. PMID: 16425296

History

- Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984;36:93-99. PMID: 6319012

- Heisterkamp N, Stephenson JR, Groffen J, et al. Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 1983;306:239-242. PMID: 6316147

- de Klein A, van Kessel AG, Grosveld G, et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1982;300:765-767. PMID: 6960256

- Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973;243:290-293. PMID: 4126434

- Nowell PC, Hungerford DA. Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 1960;25:85-109. PMID: 14427847