Thursday 19 August 2004
Most of the human genome consists of non-protein-coding DNA.
Recently, progress has been made in annotating these non-coding regions through the interpretation of functional genomics experiments and comparative sequence analysis.
One can conceptualize functional genomics analysis as involving a sequence of steps: turning the output of an experiment into a ’signal’ at each base pair of the genome; smoothing this signal and segmenting it into small blocks of initial annotation; and then clustering these small blocks into larger derived annotations and networks.
Finally, one can relate functional genomics annotations to conserved units and measures of conservation derived from comparative sequence analysis.
Annotating non-coding regions of the genome. Alexander RP, Fang G, Rozowsky J, Snyder M, Gerstein MB. Nat Rev Genet. 2010 Aug;11(8):559-71. PMID: #20628352#
Gaffney DJ, Keightley PD. Unexpected conserved non-coding DNA blocks in mammals. Trends Genet. 2004 Aug;20(8):332-7. PMID: #15262402#