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testicular teratoma

Sunday 18 July 2004

Teratomas of the testis in post-pubertal patients are histologically diverse tumors that often coexist with other types of germ cell tumors.

Testicular teratoma typically consists of heterogeneous mixtures of diverse epithelial and stromal components.

Chromosome 12p abnormalities are the hallmark genetic alterations of germ cell tumors.

The fibrous stroma of testicular teratomas frequently has genetic abnormalities similar to those of the epithelial components.

Concordant chromosome 12p alterations between the fibrous stroma and epithelial elements provide further evidence that both epithelial and fibrous components of teratoma are derived from a common progenitor. (22684226)

Types

- mature testicular teratoma
- immature testicular teratoma
- testicular teratoma component in mixed germ cell tumors

LOH study (14633619)

Chr.1 50%
Chr.2 33%
Chr.9 58%
Chr.11 43%
Chr.12 20%
Chr.18 33%

- identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis (14633619)

Associations

- embryonal rhabdomyosarcoma arising in testicular teratoma of the testis (8568751, 9400455)

  • embryonal rhabdomyosarcoma arising in a testicula mature teratoma (2188021)

References

- Molecular genetic evidence supporting the neoplastic nature of fibrous stroma in testicular teratoma. Cheng L, Zhang S, Eble JN, Beck SD, Foster RS, Wang M, Ulbright TM. Mod Pathol. 2012 Jun 8. PMID: 22684226

- Motzer RJ, Amsterdam A, Prieto V, Sheinfeld J, Murty VV, Mazumdar M, Bosl GJ, Chaganti RS, Reuter VE. Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol. 1998 Jan;159(1):133-8. PMID: 9400455

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