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sacrococcygeal teratoma

Sunday 18 July 2004

Sacrococcygeal teratoma (SCT) is the most common tumor of the newborn with an incidence of 1 in 35,000 to 40,000 live births.

In the newborn, the sacrococcygeal site is located at the base of the tailbone (coccyx), is the most common location of teratomas in newborns.

Variants

- malignant transformation

Cytogenetics

- constitutional 7q deletion (14663834)
- constitutional trisomy 2p (14663834)
- constitutional t(12;15)(q13;q25) pat (12165446)

- constitutional partial trisomy 10q (10q24.3—>qter) and partial monosomy 17p (p13.3—>pter) (17295347)

Predisposition

- Currarino syndrome

  • presacral teratoma
  • anterior meningocele
  • sacral agenesis
  • anorectal malformation

See also

- congenital germ cell tumors (CGCTs) or neonatal germ cell tumors (NGCTs)
- malignant transformation of sacrococcygeal teratoma (20113846)

References

- Malignant transformation of an untreated congenital sacrococcygeal teratoma: a amplification at 8q and 12p detected by comparative genomic hybridization. Golas MM, Gunawan B, Raab BW, F├╝zesi L, Lange B. Cancer Genet Cytogenet. 2010 Feb;197(1):95-8. PMID: 20113846

- Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. Drut R. Histopathology. 2009 May;54(6):763; PMID: 19438750

- Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. Busch C, Oppitz M, Wehrmann M, Schweizer P, Drews U. Histopathology. 2008 May;52(6):717-30.PMID: 18439155

- Heerema-McKenney A, Harrison MR, Bratton B, Farrell J, Zaloudek C. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005 Jan;29(1):29-38. PMID: 15613854

- Sebire NJ, Fowler D, Ramsay AD. Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases. Fetal Pediatr Pathol. 2004 Sep-Dec;23(5-6):295-303. PMID: 16137166

- Prenatal diagnosis of sacrococcygeal teratoma with constitutional partial monosomy 7q/trisomy 2p. Le Caignec C, Winer N, Boceno M, Delnatte C, Podevin G, Liet JM, Quere MP, Joubert M, Rival JM. Prenat Diagn. 2003 Dec 15;23(12):981-4. PMID: 14663834

- Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, Hawkins EP. Immature teratomas in children: pathologic considerations: a report from the combined Pediatric Oncology Group/Children’s Cancer Group. Am J Surg Pathol. 1998 Sep;22(9):1115-24. PMID: 9737245

- Sacrococcygeal teratoma in a fetus with prenatally diagnosed partial trisomy 10q (10q24.3—>qter) and partial monosomy 17p (p13.3—>pter). Batukan C, Ozgun MT, Basbug M, Caglayan O, Dundar M, Murat N. Prenat Diagn. 2007 Apr;27(4):365-8. PMID: 17295347

Portfolio

  • Sacrococcygeal teratoma
  • Sacrococcygeal teratoma
  • Sacrococcygeal teratoma (Macroscopy)
  • Sacrococcygeal teratoma (SCT) (Macroscopy)
  • Sacrococcygeal teratoma (SCT) (Macroscopy)
  • Sacrococcygeal teratoma (SCT) (Macroscopy)
  • Congenital sacrococcygeal immature teratoma
  • Congenital sacrococcygeal immature teratoma
  • Congenital sacrococcygeal immature teratoma
  • Congenital sacrococcygeal immature teratoma