Home > A. Molecular pathology > PPARG

PPARG

MIM.601487

Monday 5 July 2004

Pathology

- fusion gene

  • PAX8/PPARG fusion gene in thyroid follicular tumors

- constitutional mutations

  • in autosomal dominant familial partial lipodystrophy (MIM.604367)
  • in severe insulin resistance and type II diabetes (MIM.125853)
  • overrepresentation of a 1347C-T polymorphism in the PPARG gene in american patients with glioblastoma (MIM.137800)

- somatic mutation of PPARG

  • in colorectal adenocarcinoma

See also

- PPARs

References

- Campbell IW. The Clinical Significance of PPAR Gamma Agonism. Curr Mol Med. 2005 May;5(3):349-63. PMID: #15892654#

- Zhang L, Chawla A. Role of PPARgamma in macrophage biology and atherosclerosis. Trends Endocrinol Metab. 2004 Dec;15(10):500-5. PMID: #15541649#

- Lee CH, Evans RM. Peroxisome proliferator-activated receptor-gamma in macrophage lipid homeostasis. Trends Endocrinol Metab. 2002 Oct;13(8):331-5. PMID: #12217489#

Portfolio