Tuesday 29 June 2004
Morphogenesis involves coordinated proliferation, differentiation and spatial distribution of cells.
Lengthening of renal tubules is associated with mitotic orientation of cells along the tubule axis, demonstrating intrinsic planar cell polarization
Mitotic orientations are significantly distorted in rodent polycystic kidney models. Oriented cell division dictates the maintenance of constant tubule diameter during tubular lengthening and that defects in this process trigger renal tubular enlargement and cyst formation.
Affolter M, Bellusci S, Itoh N, Shilo B, Thiery JP, Werb Z. Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell. 2003 Jan;4(1):11-8. PMID: #12530959#