- Human pathology

Home > E. Pathology by systems > Skin > cutaneous clear cell tumors

cutaneous clear cell tumors

Wednesday 28 December 2016


- Clear cell hidradenoma

Practice points

· clear cell neoplasms of the skin comprise a broad variety of pri-mary and metastatic, benign and malignant lesions of epithelial, mesenchymal, melanocytic origins
· correct diagnosis relies upon careful analysis of histologic fea¬tures with the frequent use of supporting immunohistochemical and even molecular studies
· adnexal clear cell carcinoma with comedonecrosis is a newly described, clinically aggressive teston histologically characterized by a dermal proliferation with zonation of cytologic features (peripheral squamous cells, intermediate clear cells, and central necrosis)
· cutaneous clear colt sarcoma may be distinguished from clear cell melanoma by identification of the characteristic cytogenetic hallmark t(12,22)(q13;q12) resulting in a chimeric EWSR//ATF/ gene
· care must be taken to avoid misinterpretation of epidermotropic metastases from an internat organ clear cell neoplasm as a pri-mary cutaneous pagetoid disease. Caution should be exerted when evaluating pagetoid lesions in patients with known primary matignancies


-  epidermal tumors / epidermal neoplasms
- * clear cell acanthoma

- adnexal tumors / adnexal neoptasms

Clear cell myoepithelioma

Clear oeil dermatofibroma
Clear cell atypical fibroxanthoma
Xanthoma with clear cell change

Mesenchymal neoplasms
Clear cell granular oeil tumour
Clear oeil fibrous papule
Cellular neurothekeoma
Primary cutaneous perivascular epithelioid cell tumour (PEComa)
Distinctive dermal clear cell mesenchymal neoplasm
Clear cell sarcoma
Epithelioid leiomyosarcoma
Epithelioid angiosarcoma
(Malignant) glomus tumour

Balloon cell nevus
Clear cell melanoma

Short list

- benign

  • Primary cutaneous perivascular epithelioid cell tumour (PEComa )
  • dermal clear cell mesenchymal tumor

- malignant

See also

- cutaneous tumors
- clear cell tumors


- Dr GeronimGe//