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linear IgA bullous dermatosis

Tuesday 29 June 2004

CLINICAL FEATURES:
- childhood onset within 5-6 years of birth (chronic bullous disease of childhood)
- adult onset in 6-8th decades
- often antecedent infection
- annular erythemaous patches with tense blisters at edges
- trunk and extremities most often affected

HISTOPATHOLOGICAL FEATURES:
- subepidermal blister
- neutrophils linearly aligned along dermal-epidermal junction
- papillary dermal edema
- occasional eosinophils

IMMUNOFLUORESCENCE:
- linear IgA and C3 along dermal-epidermal junction
- immune deposits localize to roof of blister in most cases

DIFFERENTIAL:
- dermatitis herpetiformis
- bullous arthropod bite reaction
- Sweet syndrome
- bullous lupus erythematosus
- epidermolysis bullosa acquisita

RETURN TO: subepidermal blistering diseases

References

- Legrain V, Taieb A, Surleve-Bazeille JE, Bernard P, Maleville J. Linear IgA dermatosis of childhood: case report with an immunoelectron microscopic study. Pediatr Dermatol. 1991 Dec;8(4):310-3. PMID: 1792205

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