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targetoid hemosiderotic hemangioma

Monday 23 June 2003

hobnail hemangioma ; Hobnail Hemosiderotic Targetoid Hemangioma

Definition: Targetoid hemosiderotic hemangioma is a distinctive, benign vascular tumor.

Images

- Hobnail Hemosiderotic Targetoid Hemangioma

Epidemiology

- mostly sporadic
- rare familial occurence (11115185)

Microscopical synopsis

- biphasic growth pattern
- dilated vascular structures in the superficial dermis lined by prominent hobnail endothelial cells
- collagen dissecting, rather narrow neoplastic vessels in deeper parts of the lesion
- hobnailed endothelial cells;
- no atypia .

Immunochemistry

- CD31 + (100%) (10472756)
- CD34 +/- (8%) (10472756)
- VEGFR-3 (50%) (10472756)
- D2-40+

Differential diagnosis

- cavernous lymphangioma
- lymphangioma circumscriptum
- retiform hemangioendothelioma
- progressive lymphangioma
- Dabska’s tumor

See also

- vascular tumors

References

- Franke FE, Steger K, Marks A, Kutzner H, Mentzel T. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol. 2004 May;31(5):362-7. PMID: 15059220

- And: 3170814, 1498402, 2118554, 10472756