Home > E. Pathology by systems > Skin > cutaneous mastocytosis
cutaneous mastocytosis
Thursday 17 June 2004
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cutaneous mastocytoma
- https://twitter.com/azdermpath/status/733398395876859904
- https://twitter.com/smlungpathguy/status/745948369311272961
- https://twitter.com/Valdebran/status/753593330441695232
- https://twitter.com/phmckee1948/status/853895752510304256
systemic mastocytosis : 6/M urticaria, Darier sign+; Metachromatic staining of granules by Giemsa.
VARIANTS
solitary mastocytoma
urticaria pigmentosa
systemic mastocytosis
TMEP (telangiectasia macularis eruptiva perstans)
DERMATOPATHOLOGY: First 3 variants have perivascular or diffuse mast cells within the upper dermis with occasional subepidermal bulla formation. TMEP has telangiectatic vessels with increased perivascular mast cells (>10 mast cells per 40x field). Mast cells are highlighted with Giemsa or toluidine blue special stains. Immunohistochemistry with CD117 antibodies may also be used.
DIFFERENTIAL: collections of mast cells may resemble nevus cells, histiocytes, Langerhans cells, and leukemic infiltrates
Synopsis
"fried egg" appearance
subepidermal blister formation
See also
mastocytic anomalies
- mastocytosis / mastocytoses
